MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor.

MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor.

Blog Article

MicroRNAs play key roles in tumor metastasis.Here, we describe the regulation and function of miR-218 in gastric cancer (GC) metastasis.miR-218 expression is decreased along with the NEFF KI7862FF0G Integrated 60/40 Frost Free Fridge Freezer expression of one of its host genes, Slit3 in metastatic GC.However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop.

Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in TENS Therapy vitro and in vivo.Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis.Targeting miR-218 may provide a strategy for blocking tumor metastasis.